求翻译：早在1969年人们就发现金属铂类对实验小鼠具有很强的抗癌活性，随后的研究证实它对人类肿瘤细胞也具有较好的杀伤治疗作用 ，因此国内外越来越多的科研工作者将铂类物质作为一种先导化合物，开发出一系列的铂类抗癌药物并广泛应用于各种恶性肿瘤包括脑胶质瘤的治疗，但第一代铂制剂具有很多种毒副作用，其中包括肾毒性、消化道毒性、耳毒性和骨髓抑制等，严重局限了药物的临床使用范围。是什么意思？

As early as 1969, people found that the metal platinum has a strong anti-cancer activity in experimental mice, subsequent studies have confirmed its human tumor cells also has good anti-therapeutic effects, so more and more research work at home and abroad will be platinum material as a lead compoun

As early as in 1969 it was found that metal platinum class with the lab mice are highly active anti-cancer, and the subsequent research has confirmed it in human tumor cells also have a good anti-therapeutic role, both at home and abroad as an increasing number of researchers will be platinum class

Early in 1969 people on found metal Platinum class on experimental small rat has is strong of anticancer activity, then of research confirmed it on human tumor cell also has better of anti treatment role, so both at home and abroad increasingly more of research workers will Platinum class material a