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  • 匿名
关注:1 2013-05-23 12:21

求翻译:瞬时表达的Tax蛋白较稳定表达的Tax蛋白更能抑制HMGB1的表达;ConA能促进HMGB1的表达,但不受HMGB1的调控序列的长度影响。PCMV-Tax、PCMV-neo(对照组)、和Tax 突变体(M22、M47)分别同时与5号质粒(-983bp~+75bp)共转染的结果显示Tax、M22抑制HMGB1的表达,而M47不能影响HMGB1的调控表达。结论 Tax蛋白能抑制T细胞中(-1528bp~+75bp) HMGB1基因的调控表达,可能通过CREB途径,抑制位点在(-91bp~+75bp) HMGB1调控区,此为ATL的基因治疗提供了新思路。是什么意思?

待解决 悬赏分:1 - 离问题结束还有
瞬时表达的Tax蛋白较稳定表达的Tax蛋白更能抑制HMGB1的表达;ConA能促进HMGB1的表达,但不受HMGB1的调控序列的长度影响。PCMV-Tax、PCMV-neo(对照组)、和Tax 突变体(M22、M47)分别同时与5号质粒(-983bp~+75bp)共转染的结果显示Tax、M22抑制HMGB1的表达,而M47不能影响HMGB1的调控表达。结论 Tax蛋白能抑制T细胞中(-1528bp~+75bp) HMGB1基因的调控表达,可能通过CREB途径,抑制位点在(-91bp~+75bp) HMGB1调控区,此为ATL的基因治疗提供了新思路。
问题补充:

  • 匿名
2013-05-23 12:21:38
The tax protein transient expression of a more stable tax protein expression can inhibit hmgb1 the expression; the cona able to promote hmgb1 expression, but not by the influence of the length of the the hmgb1 regulatory sequences. -the tax pcmv, pcmv-neo (control group), and tax mutants (m22, m47),
  • 匿名
2013-05-23 12:23:18
Instantaneous expression of the expression of a relatively stable protein Tax Tax protein more capable of inhibiting the expression 1 HMGB ConA can promote HMGB; 1 of 1 HMGB Express, but are not subject to the regulation and control of the sequence length. - Tax PCMV , PCMV - neo (control group), an
  • 匿名
2013-05-23 12:24:58
Instantaneous expression Tax the protein stable expression Tax protein can suppress HMGB1 the expression; ConA can promote the HMGB1 expression, but not HMGB1 regulative sequence length influence.PCMV-Tax, PCMV-neo (control group), and the Tax mutant (M22, M47) distinguishes at the same time the res
  • 匿名
2013-05-23 12:26:38
Instantaneous Tax protein expression of a more stable Tax protein expression can inhibit the expression of HMGB1; ConA can promote the expression of HMGB1, but not under the influence of HMGB1 regulatory sequences of length. PCMV-Tax, and PCMV-neo (the control group), and Tax mutants (M22, M47) sepa
  • 匿名
2013-05-23 12:28:18
 
 
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