求翻译：Hes1做为notch信号通路中的一个负性转录控制因子，可以通过抑制细胞周期蛋白依赖性激酶抑制蛋白的转录而直接促成祖细胞的增殖加速。在胚胎的脑组织中，神经祖细胞状态的保持也需要Ｈｅｓ１的适当表达是什么意思？

hes1 notch signaling pathway as a negative control of transcription factors, can inhibit cyclin-dependent kinase inhibitor transcription and directly contributed to the proliferation of progenitor cells to accelerate. In the embryonic brain tissue, neural progenitor cells need to maintain the state

Route 1 is Hes notch signal in the transcription of a negative factor that can be controlled through inhibiting cell cycle dependent protein kinase inhibition of transcription and protein of Cho cells directly contribute to accelerate the multiplication. In embryonic brain tissue, nerve Cho cells in

Hes1 does is in a notch signal passage negative duplication control factor, may facilitate the ancestor cell directly through the suppression cell cycle protein dependent activating enzyme suppression protein duplication the multiplication acceleration.In the embryo brain organization, the nerve anc

Hes1 as a negative transcription in the notch signaling pathway controlling factor, can inhibit cyclin-dependent kinase inhibits transcription of proteins and directly lead to a proliferation of progenitor cells to accelerate. Embryonic brain, neural progenitor cells maintain Hes1 appropriate expres