求翻译：3.3　实验动物由单一性模型向特征性模型发展　一是利用体内和体外技术,在整体水平、器官水平、细胞水平、亚细胞水平和分子水平层次分明地进行毒理研究;二是利用转基因和基因敲除等技术制备的动物、细胞模型,替代或部分替代现行采用的健康动物,特别是药物毒性的评价将采用某一功能缺陷或不同程度的疾病模型。;三是发展符合替代(replacement)、减少(reduction)、优化(refinement)、责任心或可靠性(responsibility)4R原则的试验方法,更多地采用替代动物和替代试验。是什么意思？

3.3 from the unitary model of experimental animal models to develop one using the characteristic in vivo and in vitro techniques, the overall level, organ level, cellular level, sub-cellular level and molecular level structured to carry out toxicology; second is the use of transgenic and gene Prepar

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3.3 experimental animals develop by the unitary model to the characteristic value model one are use in vivo and in vitro technology, in the overall level, the organ level, the cell level, the Asian cell level and the molecular level each level clearly demarcated conducts the toxicology research; Two

3.3 experimental animal by single sexual model to features sexual model development a is using body and body outside technology, in overall level, and organ level, and cell level, and Asia cell level and molecular level levels distinct to for HIV acting research; II is using transgenic and gene knoc

3.3 experimental animal by single sexual model to features sexual model development a is using body and body outside technology, in overall level, and organ level, and cell level, and Asia cell level and molecular level levels distinct to for HIV acting research; II is using transgenic and gene knoc