求翻译：MTX的毒副作用限制了其临床应用，主要表现为胃肠道道反应和骨髓抑制，肾脏损伤常出现在高剂量时，妊娠早期使用可致畸胎是什么意思？

mtx the toxic side effects limit its clinical application, mainly for gastrointestinal Daodao reaction and bone marrow suppression, kidney damage often occurs at high doses, the use of early pregnancy can be teratogenic

The MTX drug side effects limit its clinical application, and the major manifestations of gastrointestinal tract and bone marrow suppression response stirs, kidney damage can occur when the high-dose use, early pregnancy may be teratogenic

The MTX poisonous side effect has limited its clinical practice, the main performance for a gastro-intestinal tract response and the marrow suppression, the kidney damage often appears when the high dose, the pregnancy early time use may send the monstrosity

MTX side effects limited its clinical application, mainly for reaction of gastrointestinal tract and bone marrow suppression, kidney injury often occurs when high doses, early in pregnancy can cause teratomas

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